Grupos de investigación - Bases Moleculares de la Plasticidad Neuronal

Mecanismos moleculares y celulares subyacentes a la plasticidad sináptica. Desarrollo de biosensores fluorescentes para el seguimiento de la señalización asociada a la función sináptica

Publicaciones más relevantes

Neurogranin, a link between calcium/calmodulin and protein kinase C signaling in synaptic plasticity. FJ Díez‐Guerra. IUBMB life 62 (8), 597-606. Neurogranin binds to phosphatidic acid and associates to cellular membranes. I Domínguez-González, SN Vázquez-Cuesta, A Algaba, FJ Díez-Guerra. Biochemical Journal 404 (1), 31-43. Activity-dependent translocation of neurogranin to neuronal nuclei. A Garrido-García, B Andrés-Pans, L Durán-Trío, FJ Díez-Guerra Biochemical Journal 424 (3), 419-429. The Cdk5‐p35 kinase associates with the Golgi apparatus and regulates membrane traffic. G Paglini, L Peris, J Diez‐Guerra, S Quiroga, A Cáceres. EMBO reports 2 (12), 1139-1144. “Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62”. Angelina Rodriguez, Angeles Durán, Mohammed Selloum, Marie-France Champy, F Javier Diez-Guerra, Juana María Flores, Manuel Serrano, Johan Auwerx, María T. Diaz-Meco, and Jorge Moscat. Cell Metabolism 3, 211-222

Proyectos más relevantes

"Regulation by microRNAs of glutamatergic synapses in ischemia. Development of non-invasive techniques for the study of neurotransmission mediated by glutamate", 2014-2016, SAF2014-55686-R. "Function of Neurogranin in Synaptic Plasticity", reference BFU2010-18297, 2011."Functional analysis of GMC proteins as agents of neuronal plasticity. "In situ" study by means of FRET microscopy, 2003-2005, BFI2002-01581. "Platform for the Development of Animal Health Control Strategies" (PLATESA), ref. P2013 / ABI-2906, Comunidad de Madrid, 2014-2018. “Development of antibody-based probes for the identification, localization and quantification of molecules involved in neuronal function” EMD Millipore Corporation (Merck Group)& FUAM (2016-)