Nuclear mechanotransduction and its impact in cardiovascular disease

Línea de investigación

Mechanobiology.

Descripción

Caveolae are important mechanosensing and mechanotransducer structures playing a key role in membrane tension homeostasis, contributing to various mechanotransduction pathways. Our laboratory has identified a close proximity between caveolae and the nuclear envelope in several cell and mouse models, suggesting a potential novel function in nuclear mechanotransduction with significant clinical implications, such as progeria and atherosclerosis. The master student will pursue a project aimed at exploring how mechanical signals are detected and transmitted throughout the cell by caveolae, focusing on how these signals reach the nucleus and the impact of caveolae on this organelle. S/he will combine proximity labelling, molecular biology and imaging approaches.

Contacto

Miguel Angel del Pozo Barriuso.

Correo electrónico: madelpozo@cnic.es

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC).

Número de plazas: 1.