Mechanisms integrating blood flow sensing, arterial wall remodeling and inflammation during atherogenesis

Línea de investigación

Mechanobiology.

Descripción

While most cardiovascular risk factors act systemically, atherosclerotic lesions develop at arterial regions subjected to disturbed flow (typically, inner curvatures and bifurcations), which promote atherogenic wall remodeling, eliciting LDL retention and immune cells-infiltration, driving disease progression. Conversely, regions subjected to laminar blood flow are protected from atherosclerosis. The CICERONE student will study in vitro and in vivo molecular mechanisms regulating blood flow sensing and transduction, LDL transcytosis & retention, endothelial to mesenchymal transition (endoMT) and arterial matrix remodeling under atherogenic conditions. This project falls within the context of the AtheroConvergence international consortium. 

Contacto

Miguel Angel del Pozo Barriuso.

Correo electrónico: madelpozo@cnic.es

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC).

Número de plazas: 1.