Synthesis of the Gln-tRNAGln: a singular control of mitochondrial protein biosynthesis

Línea de investigación

Identification and Characterization of genes involved mitochondrial OXPHOS Function.

Descripción

The concept that each amino acid has its own aminoacyl tRNA synthetase is a fundamental principle in translation. However, in mitochondria there are only 19 aaRSs, missing the glutaminyl-tRNA synthetase (QARS2). The formation of mitochondrial Gln-tRNAGln uses an indirect route where tRNAGln is initially misaminoacylated by a non-discriminant EARS2 to form Glu-tRNAGln. This is then followed by a transamidation reaction that converts it to Gln-tRNAGln, using glutamine as the amide donor. This transamidation process is catalyzed by the heterotrimeric enzyme complex glutamyl-tRNAGln amidotransferase, hGatCAB.

Contacto

Miguel Ángel Fernández Moreno.

Correo electrónico: miguel.fernandez@uam.es.

Departamento de Bioquímica (UAM).

Número de plazas ofertadas: 1.