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Oligomeric structure of GlyT2 and hyperekplexia mutants

Línea de investigación

Physiopathological aspects of glycine transporters in glycinergic neurotransmission: hyperekplexia and pain.

Descripción

Identifying the GlyT2 dimerization interface by evaluating the dimerization capacity of a dominant negative mutant of GlyT2 trafficking (previously identified by us) both with the wild type or with truncated GlyT2 constructions. Role of PIP2 in the oligomerization of GlyT2 and human hyperekplexia variants.

Contacto

Beatriz López Corcuera, beatriz.lopez@uam.es.

Facultad de Medicina. Universidad Autónoma de Madrid. Calle del Arzobispo Morcillo 4. 28029 Madrid. Tel.: +34 914 975 486. Correo electrónico: informacion.medicina@uam.es