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Tesis doctorales

Tesis: NOVEL C#H FUNCTIONALIZATION REACTIONS ASSISTED BY 2-PYRIDYL-CONTAINING DIRECTING GROUPS

Organized by
Departamento de Química Orgánica
Speaker
Angel Manu Martínez Garzón
Date
02-03-2018
Description
  • Dirección: 
    • Carretero Gonzálvez, Juan Carlos    (Director)
    • Rodríguez Garrido, Nuria    (Director)
  • Tribunal: 
    • ASENSIO AGUILAR, GREGORIO    (presidente)
    • Bottari , Giovanni     (secretario)
    • GÓMEZ GALLEGO, MARÍA DEL MAR    (vocal)
    • RIBAS SALAMAÑA, XAVIER    (vocal)
    • Mascareñas Cid, Jose Luis    (vocal)
  • Resumen:

The catalytic functionalization of unreactive C-H bonds is an area of growing importance for the design of atom economical strategies to valuable organic molecules. However, due to the ubiquity of C-H bonds in organic molecules, achieving perfect site-selectivity and high functional group tolerance has been one of the major challenges in this area. In this context, this dissertation outlines our efforts to develop key structure building C-H functionalization reactions that streamline the construction of complex molecular skeletons based on the use of 2-pyridyl-containing directing groups. 
In particular, we have achieved:

-    The construction of C-N bonds through a Cu-catalyzed cross-dehydrogenative coupling strategy.

-    The development of a Rh-catalyzed tandem process that involves the formation of C-C and C-X bonds.

-    A switchable site-selectivity through catalyst control in the direct Rh-catalyzed functionalization of molecule that contain distinct C-H bonds.

-    A catalyst-controlled selectivity in the Rh-catalyzed C(sp2)–H functionalization with 1,3-diynes involving cyclization cascade processes.

-    The Co-catalyzed alkyne annulation of N-containing arenes through C-H/N-H functionalization. 

Tesis

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