Facultad de Ciencias

FORCHRONIC (AGL2016-76736-C3-1-R)

2017-2019
IP: Prof. Guillermo Reglero Rada 

The objective of the project FORCHRONIC is to design, develop and validate the effect and safety of new formulas for humans, effective in regulating the molecular mechanisms of cellular cholesterol transport and the activation of fatty acid synthesis, fundamental routes in the development of colorectal cancer, obesity and metabolic syndrome, in order to achieve food products with high added value, highly effective as nutritional supplements aimed at preventing and improving the treatment of these diseases.

The project is based on two hypotheses resulting from the previous project carried out by the research team within the State Program of R+D+I, Challenging the Society; The regulation of ABCA1 metabolism genes and the ACSL / SCD pathway allows the control of cholesterol transport pathways and the activation of fatty acid synthesis, associated with the development of chronic diseases such as colon cancer and the metabolic syndrome; Formulas based on the combination of polar lipids and bioactive principles of natural origin can provide for efficient regulation of metabolism genes due to potentiation of bioavailability and synergistic biological activity.