Facultad de Ciencias

Participo en la línea de investigación “Respuestas celulares inducidas por estrés químico”, que está reconocida con el grupo de investigación HuNAMs (Nuevas Aproximaciones Metodológicas para la seguridad humana y ambiental). Actualmente el grupo está financiado por el proyecto “Generación de ensayos in vitro para establecer la actividad de rutas de respuesta a estrés celular como indicadores de efectos tóxicos de aditivos y contaminantes alimentarios” (PID2022-141894OB-C22).

Profesores o investigadores vinculados al proyecto: Paloma Fernández Freire, Ana Peropadre López, Soledad Sanz Alférez, Patricia Soto Bielicka.

1. Soto-Bielicka, P., Peropadre, A., Sanz-Alférez, S., Hazen, M. J., & Fernández Freire, P. (2024). Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines. Toxicology, 153769. https://doi.org/10.1016/J.TOX.2024.1537691. 
2. Peropadre, A., Vega-Cuesta, P., Fernández Freire, P., Pulido, D., Carriere, M., de Celis, J.F. (2023). Complementary in vitro and in vivo strategies to assess the biological effects of nano-enabled food additives E171 and E551. Environmental Science-Nano. 10 (5): 1394-1412. https://doi.org/10.1039/d3en00009e.
3. Soto-Bielicka, P., Tejeda, I., Peropadre, A., Hazen, M.J., Fernández Freire, P. (2023). Detrimental cellular effects of individual versus combined exposure to tetrabromobisphenol A and polystyrene nanoplastics in fish cell lines. Environmental Toxicology and Pharmacology, 98, 104072. https://doi.org/10.1016/j.etap.2023.104072.
4. Verdú C, Pérez-Arnaiz P, Peropadre A, Berenguer J, Mencía M. Deletion of the primase-polymerases encoding gene, located in a mobile element in Thermus thermophilus HB27, leads to loss of function mutation of addAB genes. (2022) Frontiers in Microbiollogy. 13:1005862. https://www.doi.org/10.3389/fmicb.2022.1005862.
5. Ruiz-Losada M, González R, Peropadre A, Gil-Gálvez A, Tena JJ, Baonza A, Estella C. Coordination between cell proliferation and apoptosis after DNA damage in Drosophila. (2022) Cell Death and Differentiation. 29:832-845.https://dori.org/10.1038/s41418-021-00898-6.
6. Peropadre, A., Hazen, M.J., Pérez Martín, J.M., Fernández Freire, P. (2020). An acute exposure to perfluorooctanoic acid causes non-reversible plasma membrane injury in HeLa cells. Environmental Pollution, 260, 114008. https://doi.org/10.1016/j.envpol.2020.114008.
7. Peropadre, A., Fernández Freire, P., Hazen, M.J. (2018). A moderate exposure to perfluorooctanoic acid causes persistent DNA damage and senescence in human epidermal HaCaT keratinocytes. Food and Chemical Toxicology, 121, 351–359. https://doi.org/10.1016/j.fct.2018.09.020.
8. Fernández Freire, P., Peropadre, A., Rosal, R., Pérez Martín, J. M., Hazen, M. J. (2016). Toxicological assessment of third generation (G3) poly (amidoamine) dendrimers using the Allium cepa test. The Science of the Total Environment, 563–564, 899–903. https://doi.org/10.1016/j.scitotenv.2015.07.137.
9. Peropadre, A., Fernández Freire, P., Pérez Martín, J. M., Herrero, Ó., Hazen, M. J. (2015). Endoplasmic reticulum stress as a novel cellular response to di (2-ethylhexyl) phthalate exposure. Toxicology in Vitro, 30, 281–287. https://doi.org/10.1016/j.tiv.2015.10.009.
10. Fernández Freire, P., Peropadre, A., Pérez Martín, J. M., Herrero, Ó., Hazen, M. J. (2009). An integrated cellular model to evaluate cytotoxic effects in mammalian cell lines. Toxicology in Vitro, 23(8), 1553–1558. https://doi.org/10.1016/j.tiv.2009.06.017
11. Peropadre, A., Fernández Freire, P., Herrero, Ó., Pérez Martín, J. M., & Hazen, M. J. (2011). Cellular responses associated with dibucaine-induced phospholipidosis. Chemical Research in Toxicology, 24(2), 185–192. https://doi.org/10.1021/tx100262c