Science Faculty

Intramolecular Hydrogen-Bond Activation for the Addition of Nucleophilic Imines: 2-Hydroxybenzophenone as Chemical Auxiliary

Author/s

Choubane, H.; Garrido-Castro, A. F.; Alvarado, C.; Martín-Somer, A.; Guerrero-Corella, A.; Daaou, M.; Díaz-Tendero, S.; Maestro, C.; Fraile, A.; Alemán, J.

Año de edición

2018

Referencia completa

Chem. Commun., 2018, 54, 3399--3402. DOI: 10.1039/c8cc01479e

Resumen

The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trials.