Facultad de Ciencias

Asymmetric Synthesis of Hexahydropyrrolo-isoquinolines via an Organocatalytic Three-Component Reaction

Autor/es

Fraile, A.; Scarpino Schietroma, D. M.; Albrecht, A.; Davis, R. L.; Jørgensen, K. A.

Año de edición

2012

Referencia completa

Chem. Eur. J. 2012, 18, 2773-2776. DOI: 10.1002/chem.201200108

Resumen

Merging three in one by a three‐component organocatalytic asymmetric reaction of imines and α‐bromoesters or ketones with α,β‐unsaturated aldehydes provides optically active pyrrolo‐isoquinolines—an important class of molecules in life science. The reaction proceeds with excellent enantioselectivity and a number of transformations of the products obtained demonstrated the potential of the new reaction.

Otros datos de interés

Destacado por Synfacts 2012, 8, 560