Science Faculty

Arylsulfonylacetylenes as Alkynylating Reagents of Csp2-H Bonds Activated with Lithium Bases

Author/s

García Ruano, J. L.; Alemán, J.; Marzo, L.; Alvarado, C.; Tortosa, M.; Díaz-Tendero, S.; Fraile, A.

Año de edición

2012

Referencia completa

Angew. Chem. Int. Ed. 2012, 51, 2712-2716. DOI: 10.1002/anie.201107821

Resumen

Chameleon: A new strategy for the synthesis of a wide variety of alkynyl derivatives by the reaction of substituted arylsulfonylacetylenes with organolithium species is described (see scheme). The high yields, the simplicity of the experimental procedure, the broad scope of this reaction, and the formation of C_sp-C_sp2 bonds without using transition metals are the main features of this methodology.

Otros datos de interés

Destacado como“Hot Paper” por Angew. Chem. Int. Ed. y por Synfacts 2012, 8, 660